Although may be used to prevent problems or treat people who have problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking fosinopril. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine. Irinotecan Products: UGT1A1 Inhibitors may increase serum concentrations of the active metabolites of Irinotecan Products. Specifically, concentrations of SN-38 may be increased. UGT1A1 Inhibitors may increase the serum concentration of Irinotecan Products. Pirfenidone: CYP1A2 Inhibitors Moderate may increase the serum concentration of Pirfenidone. Management: Use any such combination with caution and close monitoring for pirfenidone toxicity. Avoid the use of pirfenidone with moderate CYP1A2 inhibitors whenever CYP2C9, 2C19, 2C6, or 2E1 is also inhibited either by the CYP1A2 inhibitor or by a third drug. uroxatral today
Ask your doctor if this treatment is right for you. Acute pancreatitis may be the first sign of gallstones. Gallstones can block the pancreatic duct, which can cause acute pancreatitis. Miller NE. Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis.
Tobert JA. Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation. N Engl J Med. What Are the Symptoms of Pancreatitis? If heavy drinking is a concern, talk to your doctor or professional about a referral to an alcohol treatment center. Gemfibrozil is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely. There have been reported cases of overdosage with Lopid. In one case, a 7-year-old child recovered after ingesting up to 9 grams of Lopid. Symptoms reported with overdosage were abdominal cramps, abnormal liver function tests, diarrhea, increased CPK, joint and muscle pain, nausea and vomiting. Symptomatic supportive measures should be taken, should an overdose occur.
Antidiabetic Agents Thiazolidinedione: Gemfibrozil may decrease the metabolism of Antidiabetic Agents Thiazolidinedione. Nash DT. Gemfibrozil in combination with other drugs for severe hyperlipidemia: preliminary study comprising four cases. Postgrad Med. It is very important to continue to follow your doctor's advice about diet and exercise. It may take up to 3 months before you get the full benefit of this drug. Each tablet contains 600mg of Gemfibrozil as the active ingredient.
Older adults may be more sensitive to the side effects of this drug, including dizziness and increases in potassium level. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Okerholm RA, Keeley FJ, Peterson FE et al. The metabolism of gemfibrozil. Proc R Soc Med. Avoid eating foods that are high in fat or cholesterol. Gemfibrozil will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Possible subcapsular bilateral and unilateral cataracts. Tandberg, D. and Murphy, L. C. The knee-chest position does not improve the efficacy of ipecac-induced emesis.
Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Tharratt, S. R. Superiority of activated charcoal alone compared with ipecac and activated charcoal in the treatment of acute toxic ingestions. Ann. Sekowski I, Samuel P. Clofibrate-induced acute muscular syndrome. Am J Cardiol. Fremouw, W. J. Ipecac abuse: a serious complication in bulimia. Gen. Remember that it is best to get your and from food whenever possible. Maintain a well-, and follow any dietary guidelines as directed by your doctor. If you also take a bile acid-binding resin eg, colestipol do not take it within 2 hours before or after taking Lopid. Check with your doctor if you have questions. Pravastatin acts as a lipoprotein-lowering drug through two pathways. The first and major pathway is to inhibit HMG-CoA hydroxymethylglutaryl-CoA reductase. Its function as a reversible competitive inhibitor means it works by sterically hindering HMG-CoA by occupying the active site of the enzyme. Discuss the risks and benefits with your doctor. strattera
National Institutes of Health Office of Medical Applications of Research. Consensus Conference: lowering blood cholesterol to prevent heart disease. JAMA. Gemfibrozil is in a class of drugs called fibrates. It works by reducing the production of triglycerides in the liver. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. CYP2C8 with subtherapeutic gemfibrozil doses. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. brand depakote kaufen depakote
Ratiopharm, Sandoz, Cipla Medpro, Pharmadynamics and IntelliPharmaCeutics. What Lopid is and what it is used for. Monitor creatine kinase CK, creatine phosphokinase, CPK concentrations in patients reporting adverse musculoskeletal effects. 1 108 116 Discontinue therapy if myositis is suspected or diagnosed. Rosuvastatin: Gemfibrozil may enhance the myopathic rhabdomyolysis effect of Rosuvastatin. Gemfibrozil may increase the serum concentration of Rosuvastatin. Management: If possible, avoid concomitant use of rosuvastatin with gemfibrozil. Reference Listed Drug RLD is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application ANDA. By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart. cvs pharmacy persantine prices
Amodiaquine: CYP2C8 Inhibitors may increase the serum concentration of Amodiaquine. This drug may rarely cause serious possibly fatal problems. Dasabuvir: CYP2C8 Inhibitors Strong may increase the serum concentration of Dasabuvir. Dry may also occur. If any of these effects persist or worsen, tell your doctor or promptly. Leiss O, von Bergmann K, Gnasso A et al. Effect of gemfibrozil on biliary lipid metabolism in normolipemic subjects. Metabolism. Major API manufacturers such as Merck, AstraZeneca and GlaxoSmithKline are also moving away from multifunctional plants and instead opting for specific activities at specific sites. In this way, there are serious concerns as to how any centralized control could function as after all an API manufactured by one company, in one country, with the excipient manufactured in another by a different company, then packaged and distributed by another company altogether makes the route rather difficult to monitor or control. HDL-cholesterol concentrations in addition to elevated LDL-cholesterol and triglycerides. Carvedilol: CYP2C9 Inhibitors Strong may increase the serum concentration of Carvedilol. Specifically, concentrations of the S-carvedilol enantiomer may be increased. However, do not use gemfibrozil with statins because of increased risk of adverse muscle effects and rhabdomyolysis. 350 When combined statin and fibric acid derivative therapy is required, fenofibrate is considered drug of choice; 350 however, addition of fenofibrate to simvastatin therapy in patients with diabetes mellitus not shown to substantially reduce major adverse cardiovascular events compared with statin monotherapy.
PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lopid while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Lopid. Male rats had a dose-related and statistically significant increase of benign Leydig cell tumors. The higher dose female rats had a significant increase in the combined incidence of benign and malignant liver neoplasms. Rasi VPO, Torstila I. Effect of gemfibrozil upon platelet function and blood coagulation. preliminary report. Proc R Soc Med. For best results, Lopid should be used along with exercise, a low-cholesterol and low-fat diet, and a weight loss program if you are overweight. Follow the diet and exercise program given to you by your health care provider. Consider use of alternative antilipemic therapy against the risks and benefits of a lower dose of gemfibrozil. Note: No generic formulation of the following product is available. Though there are some proposed mechanisms of action, there is no real consensus and much still needs to be researched about how gabapentin actually works. According to one study halting the formation of new synapses in the brain causes the resultant analgesic effect. Frick MH, Elo O, Haapa K et al. Helsinki Heart Study: primary prevention trial with gemfibrozil in middle-aged men with dyslipidemia: safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med. Langer T, Levy RI. Acute muscular syndrome associated with administration of clofibrate. N Engl J Med. Decreases serum concentrations of triglycerides, 1 15 16 17 18 19 21 22 23 24 26 27 28 29 30 32 33 37 38 45 48 76 91 104 VLDL-cholesterol, 1 15 17 18 19 25 33 37 38 45 48 76 and, to a lesser extent, LDL-cholesterol. 1 15 33 37 38 45 76 Increases HDL-cholesterol. 1 15 16 19 21 22 24 25 26 31 32 33 36 38 45 88 91 Causes a variable reduction in serum total cholesterol, 1 15 16 17 18 19 21 24 25 26 27 28 29 30 31 32 33 37 38 48 68 105 106 because the decrease in serum cholesterol is a net result of a decrease in VLDL-cholesterol, 18 19 21 25 26 28 32 33 38 45 an increase in HDL-cholesterol, 37 68 and an increase 15 21 30 33 37 45 91 or decrease in LDL-cholesterol. Importance of informing patients of other important precautionary information. 1 See Cautions. Pickering JE. Clinical results with gemfibrozil. Am J Cardiol. Some cases of severe pancreatitis can result in death of pancreatic tissue. In these cases, surgery may be necessary to remove the dead or damaged tissue if an infection develops. canada lopid brands
Manninen V, Elo O, Frick MH et al. Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA. Tuomilehto J, Salonen J, Kuusisto P et al. A clofibrate controlled trial of gemfibrozil in the treatment of hyperlipidaemias. Proc R Soc Med. By drawing these distinctions between APIs and the drugs themselves, manufacturers are able to specialize and pharmacists able to align generic equivalents with brand names. This is of vital important and underlies one of the most solid principles and regulations of modern pharmacy. But meds can have side effects. Please refer to the for information on shortages of one or more of these preparations. The Active Pharmaceutical Ingredient Industry is the organ by which active pharmaceutical ingredients are manufactured from raw materials through both chemical and physical means. Depending on the complexity of the molecule required, synthesis of APIs might need multi-step complex chemistry utilizing a range of processing technologies. Oral: 600 mg twice daily 30 minutes before breakfast and dinner. Note: Discontinue if lipid response is inadequate after 3 months of therapy. Because of chemical, pharmacological, and clinical similarities between gemfibrozil and clofibrate, the adverse findings with clofibrate in two large clinical studies may also apply to gemfibrozil. In the first of those studies, the Coronary Drug Project, 1000 subjects with previous myocardial infarction were treated for five years with clofibrate. There was no difference in mortality between the clofibrate-treated subjects and 3000 placebo-treated subjects, but twice as many clofibrate-treated subjects developed cholelithiasis and cholecystitis requiring surgery. In the other study, conducted by the World Health Organization WHO 5000 subjects without known coronary heart disease were treated with clofibrate for five years and followed one year beyond. There was a statistically significant 44% higher age-adjusted total mortality in the clofibrate-treated group than in a comparable placebo-treated control group during the trial period. The excess mortality was due to a 33% increase in non-cardiovascular causes, including malignancy, post-cholecystectomy complications, and pancreatitis. The higher risk of clofibrate-treated subjects for gallbladder disease was confirmed. The resulting effect is a reduction of triglyceride levels, reduction of very low density lipoprotein VLDL levels and a minor reduction of LDL levels. It also results in a small increase in high density lipoprotein HDL levels. The recommended dosage of gemfibrozil is 600 mg half-an-hour before breakfast and dinner. Severe problems may occur. Monitor blood cell counts periodically during the first 12 months of therapy. This information should not be used to decide whether or not to take Lopid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Lopid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Lopid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Lopid. Ezetimibe. Specifically, the risk of myopathy and cholelithiasis may be increased. Gemfibrozil may increase the serum concentration of Ezetimibe. Tenenbein, M. Efficacy of ipecac during the first hour after drug ingestion in human volunteers. Mahley RW. Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology. Circulation. Gemfibrozil AUC was reduced by 30% when gemfibrozil was given 600 mg simultaneously with resin-granule drugs such as colestipol 5 g. Administration of the drugs two hours or more apart is recommended because gemfibrozil exposure was not significantly affected when it was administered two hours apart from colestipol. umud.info doxylamine
Talk to your doctor or pharmacist before taking Lopid. Squibb Company July, 2016. Lopid should be taken orally. Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day. It is important to continue taking this medication even if you feel well. Most people with not feel sick. The Long-term Intervention with Pravastatin in Ischaemic Disease LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. Mac Carthy EP. Dear Doctor letter regarding market withdrawal of Baycol cerivastatin. Colchicine: Fibric Acid Derivatives may enhance the myopathic rhabdomyolysis effect of Colchicine. Enzalutamide: CYP2C8 Inhibitors Strong may increase the serum concentration of Enzalutamide. Management: Avoid concurrent use of strong CYP2C8 inhibitors and enzalutamide if possible. If the combination must be used, reduce enzalutamide to 80 mg once daily. WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report from the Committee of Principal Investigators. Lancet. Plasma concentrations do not appear to correlate with therapeutic response. Bossen, E. Ipecac myopathy and cardiomyopathy. glucotrol
The drug was approved by the Food and Drug Administration FDA in 1993. Other manufacturers of the extended release venlafaxine include: TAPI, Cobalt Pharmaceuticals Inc. Monitor lipoprotein concentrations periodically. 1 Discontinue therapy in patients who fail to achieve an adequate response after 3 months of therapy. Avoid drinking alcohol. It may interfere with your treatment. The United States pharmacopeia, 21st rev, and The national formulary, 16th ed. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1985: 457. Make sure all your doctors know which medicines you are using. JH, Pearson PG, Baillie TA. Mechanistic studies on metabolic interactions between gemfibrozil and statins.
CYP2C8 Substrates: CYP2C8 Inhibitors Strong may decrease the metabolism of CYP2C8 Substrates. Raltegravir: May enhance the myopathic rhabdomyolysis effect of Fibric Acid Derivatives. Pravastatin also works as an inhibitor of very low-density lipoproteins which leads to an increase in the number of cellular LDL receptors, thus increasing LDL uptake and removing it from the bloodstream. The end result is a reduction in circulating cholesterol and LDL. Minor reductions in triglycerides and increases in high-density lipoproteins HDL are also common. The Expert Panel. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel II. Circulation. In most cases, acute pancreatitis is caused by or heavy alcohol use. It is recommended that you do not take Lopid while you breast-feed. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Sacks FN, Pfeffer MA, Maye LA et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. Schwandt P, Weisweiler P, Neureuther G. Serum lipoprotein lipids after gemfibrozil treatment. Artery. The most frequently reported side effects were gastrointestinal reactions and included dyspepsia, abdominal pain, diarrhea, nausea, vomiting, acute appendicitis, constipation, and flatulence. Pioglitazone: CYP2C8 Inhibitors Strong may increase the serum concentration of Pioglitazone. Crestor rosuvastatin calcium US prescribing information. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. If your symptoms do not improve or if they become worse, check with your doctor. Like all statins, Simvastatin works by inhibiting 3-hydroxy-3-methylglutaryl HMG-CoA in the rate-limiting step of the metabolic pathway that leads to cholesterol production. cefadroxil money order online store
Rosenberg, N. L. and Ringel, S. P. Myopathy from surreptitious ipecac ingestion. Gabapentin is a GABA analogue originally developed to treat epilepsy and epileptic seizures. A seizure is a short episode where there is an abnormal burst of electrical activity in the brain. Gabapentin works by reducing the amount of electrical activity occurring and in this way controls the seizures and their symptoms. However, how exactly it does this is not fully known. Appears to be metabolized in the liver to 4 major metabolites produced via 3 metabolic pathways. 2 7 102 A phenol derivative metabolite I 2 7 is pharmacologically active. No preemptive dose adjustment is recommended for other treprostinil products. Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. Lancaster, K. L. The eating disorders medicine cabinet revisited: a clinician's guide to ipecac and laxatives. Int J Eat. This may interfere with certain laboratory tests including levels possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The initial treatment for dyslipidemia is dietary therapy specific for the type of lipoprotein abnormality. Excess body weight and excess alcohol intake may be important factors in hypertriglyceridemia and should be managed prior to any drug therapy. Physical exercise can be an important ancillary measure, and has been associated with rises in HDL-cholesterol. Diseases contributory to hyperlipidemia such as hypothyroidism or diabetes mellitus should be looked for and adequately treated. Estrogen therapy is sometimes associated with massive rises in plasma triglycerides, especially in subjects with familial hypertriglyceridemia. In such cases, discontinuation of estrogen therapy may obviate the need for specific drug therapy of hypertriglyceridemia. The use of drugs should be considered only when reasonable attempts have been made to obtain satisfactory results with nondrug methods. If the decision is made to use drugs, the patient should be instructed that this does not reduce the importance of adhering to diet. If you forget to take a dose, do not worry. The cause of the interaction is not known. This enzyme is primarily responsible for the conversion of HMG-CoA to mevalonate in the rate-limited step of the pathway for cholesterol. Patients with significantly elevated triglycerides should be closely observed when treated with gemfibrozil. In some patients with high triglyceride levels, treatment with gemfibrozil is associated with a significant increase in LDL-cholesterol. BECAUSE OF POTENTIAL TOXICITY SUCH AS MALIGNANCY, GALLBLADDER DISEASE, ABDOMINAL PAIN LEADING TO APPENDECTOMY AND OTHER ABDOMINAL SURGERIES, AN INCREASED INCIDENCE IN NON-CORONARY MORTALITY, AND THE 44% RELATIVE INCREASE DURING THE TRIAL PERIOD IN AGE-ADJUSTED ALL-CAUSE MORTALITY SEEN WITH THE CHEMICALLY AND PHARMACOLOGICALLY RELATED DRUG, CLOFIBRATE, THE POTENTIAL BENEFIT OF GEMFIBROZIL IN TREATING TYPE IIA PATIENTS WITH ELEVATIONS OF LDL-CHOLESTEROL ONLY IS NOT LIKELY TO OUTWEIGH THE RISKS. Lopid IS ALSO NOT INDICATED FOR THE TREATMENT OF PATIENTS WITH LOW HDL-CHOLESTEROL AS THEIR ONLY LIPID ABNORMALITY. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Survival Study 4S. Lancet. clarithromycin
Ipecac can irritate the digestive tract. Lopid versus 45 placebo noncoronary deaths. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Pancreatitis can happen to anyone, but it is more common in people with certain risk factors. Frank, S. D. Death due to chronic syrup of ipecac use in a patient with bulimia. However, ALA from food does not appear to produce a noticeable increase in the level of free ALA in the body. Pitavastatin: Gemfibrozil may enhance the myopathic rhabdomyolysis effect of Pitavastatin. Gemfibrozil may increase the serum concentration of Pitavastatin. Alitretinoin Systemic: CYP2C9 Inhibitors Strong may increase the serum concentration of Alitretinoin Systemic. Management: Consider reducing the alitretinoin dose to 10 mg when used together with strong CYP2C9 inhibitors. Surgery may be done in some cases to help relieve abdominal pain, restore drainage of pancreatic enzymes or hormones, treat chronic pancreatitis caused by blockage of the pancreatic duct, or reduce the frequency of attacks. Antilipemic agent; fibric acid derivative. Electron microscopy studies have demonstrated a florid hepatic peroxisome proliferation following Lopid administration to the male rat. An adequate study to test for peroxisome proliferation has not been done in humans but changes in peroxisome morphology have been observed. Peroxisome proliferation has been shown to occur in humans with either of two other drugs of the fibrate class when liver biopsies were compared before and after treatment in the same individual. Glueck CJ. Nonpharmacologic and pharmacologic alteration of high-density lipoprotein cholesterol: therapeutic approaches to prevention of atherosclerosis. Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. suprax
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Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Ursodiol: Fibric Acid Derivatives may diminish the therapeutic effect of Ursodiol. No efficacy in the patients with established coronary heart disease was observed during the Coronary Drug Project with the chemically and pharmacologically related drug, clofibrate. The Coronary Drug Project was a 6-year randomized, double-blind study involving 1000 clofibrate, 1000 nicotinic acid, and 3000 placebo patients with known coronary heart disease. A clinically and statistically significant reduction in myocardial infarctions was seen in the concurrent nicotinic acid group compared to placebo; no reduction was seen with clofibrate. online ranolazine blog
The dosage is based on your medical condition and response to treatment. If you are taking this for lipid problems, your doctor may direct you to start this medication at a low dose and gradually increase your dose to reduce your risk of side effects. Your dose will need to be increased slowly even if you are already taking niacin and are being switched from another niacin product to this product. Follow your doctor's instructions carefully. Novopharm Limited, Pharmascience Inc. There are many products available. Some can be purchased without a prescription. Consult your doctor or about the best product for you.
SLCO1B1 Inhibitors may increase the serum concentration of Grazoprevir. Swallow extended-release capsules whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Eisalo A, Manninen V. A long-term trial of gemfibrozil in the treatment of hyperlipidaemias. Proc R Soc Med.
The amount of repaglinide in your blood may increase and it may lower your blood sugar too much. Ten of these deaths in the Lopid group and 3 in the placebo group occurred after discontinuation from therapy. In this study of patients with known or suspected coronary heart disease, no benefit from Lopid treatment was observed in reducing cardiac events or cardiac deaths. Thus, Lopid has shown benefit only in selected dyslipidemic patients without suspected or established coronary heart disease. Even in patients with coronary heart disease and the triad of elevated LDL-cholesterol, elevated triglycerides, plus low HDL-cholesterol, the possible effect of Lopid on coronary events has not been adequately studied.